Many variables can effect the absorption rates of just about any available supplement, especially curcumin. Dosage size, delivery method and timing of administration, are just some of the variables known to have a tremendous impact on absorption. Unfortunately, curcumin is effected by these variables more than most other nutrients because of its rapid metabolism. This makes curcumin absorption an extreme balancing act that can be thrown off by the smallest of variables. In fact, even your sex can determine the amount of curcumin absorption you may expect.
Men Vs Women.
Believe it or not, Women can expect to absorb 30 to 40% more curcumin than men. Of course, this is due to even more variables in addition to the ones I have mentioned above. Complex variables like hepatic drug efflux transporter (MDR1), sulfotransferases, and bio-transformation enzymes can be the cause for absorption differences in Men and Women. However, more simple variables like body weight, blood volume, and body fat can also be the root cause of this variation. Either way, these added variables just further complicate an already deep and complex absorption issue.
While novel formulations of curcumin like Micelles (liquid dispersed) and Micronisate (micronized powder) can produce a 30 -40% increase in absorption for women, the same is not true for regular curcumin powder. Curcumin in its natural form performs more erratic between individuals and therefore is more difficult to compare between men and women. Formulations that combat curcumins rapid metabolism are more consistent and for that reason are able to be compared with ease.
Curcumins Achilles heel is absorption without a doubt. Researchers are working around the clock to circumvent and overcome this major hurdle. Progress is slow but none the less moving forward. With Novel curcumin formulations and science uncovering more information than ever, we have some of the best curcumin options at our finger tips. Taking into consideration simple variables like curcumin formulation, dosage size, and even your sex can increase your chances in getting the most health benefits out of your curcumin supplement.