Melatonin and IL-2 cancer treatment

Melatonin and IL-2 cancer treatment


I used to hear many cancer patients talking about melatonin. I never really payed much attention to it because I only thought it helped with sleep. And if it only helped with sleep it wasn’t worth my time. I needed to find something that would help my Mothers cancer. I actually came across it again years later while doing other research. Once I started reading about it, I knew I had to do more research on this powerful supplement. I felt I was on to something. Something different. Something great.


Combo Shows Anti-Cancer Response.

When Melatonin at 40mg/day orally along with low dose IL-2 (interleukin-2) was given to advanced ovarian cancer patients progressing on other treatments, it showed promising results. 2 out of 16 patients achieved a partial response. 5 out of the 16 patients achieved stable disease. And 5 other patients had progressive disease. Most other standard forms of treatment given to heavily pre-treated patients wouldn’t have performed as well.

10 mg Melatonin pills.

Melatonin Alone shows Cancer Response.

Another study used only 20mg/day orally which is half the dose of the first study. In addition, they did not combine it with IL-2. This time 2 out of 20 advanced cancer patients achieved a minor response. 6 out of 20 achieved a stable disease. 12 others progressed. This proves that Melatonin alone has anti-cancer activity. And remember this was at a 50% less dose. That is just amazing. Would a larger dose provide better results?


Pretty amazing supplement.

This little supplement really impressed me. Especially since it can be easily purchased over the counter at any health store. Plus it’s very cheap. It is probably one of the cheapest supplements you can buy.

Melatonin looks very strong. These studies show activity in heavily treated patients. The low dose makes this very interesting. The ability to take it orally separates it from the rest. All this just reinforces the strength it has against cancer. But we still need to study and learn more so it can be utilized to its greatest potential. We need to maximize results. Understand the mode of action. Only then we can reap all the benefits.

I will definitely keep my eyes open and report any updates.



Melatonin and IL-2 cancer treatment was last modified: August 2nd, 2017 by Cancermind
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  1. Christopher Wich 7 years ago

    Thank you for creating a site like this. This site is very helpful and informative.

  2. Chris N 7 years ago

    Thank you for the support and kind words.

    Chris @

  3. BARRY RICHARDSON 4 years ago



    • Author
      Cancermind 4 years ago


      First I’d like to thank you for such a well put together and clever comment. This is one of the best questions I have received so far. To answer your question, I really like to think I have no bias when it comes down to conventional vs natural. I base everything on credible information or the lack there of. For me everything comes down to numbers and odds. If someone wants to go the natural route then I believe they should be able to do so. The patient should have the final say no matter what. Every patient, disease, and even goals of the patient are all different and never the same. So of course the right treatment for cancer patient #1 won’t be right for cancer patient #2. But whether they decide to go natural or conventional, proper research should be done as to pick the treatment with the best odds of success based on the criteria that’s most important to that cancer patient.

      For example, if cancer patient #1 wants to use natural treatments, then why not choose a natural treatment that has positive research and potential vs a natural treatment that has either no credible research or entirely negative outcomes on studies that were performed? Many natural cancer treatments are popular based solely on testimonials. That might be ok if we lived in a honest world without scam artists trying to take advantage of cancer patients or when john doe writes a testimonial that is in fact bias in one way or the other. Even if the testimonial is not bias and coming directly from the cancer patient, information can’t be used to gauge effectiveness for a vast amount of uncontrolled data. For the most part when cancer patients use natural remedies they normally use more than one at a time. They usually give credit to the one they think was effective. Keyword is think. Even if they are trying to be as honest as possible they truly don’t know what worked and what didn’t. It’s all just a guess. The response they experienced might have not even been correlated with any natural treatments they were taking at the time and yet some will call it a cancer cure.

      Many cancer patients feel that choosing a natural cancer treatment can’t hurt any so what’s the risk? They are comparing it to chemotherapy but rarely compare it to other natural treatments. This is a huge mistake. Any natural treatment will look amazing to someone that has a bias against conventional medicine. So even natural treatments with no data or negative data are chosen by cancer patients with this sort of thinking. However, natural treatments do hold a risk. Some natural treatments can in fact increase growth and make matters a lot worse. So in these circumstances maybe choosing no treatment at all is better than playing Russian roulette with natural treatments.

      Also, some cancers have a very high survival rate when treated conventionally. But with all the negative comments made by bias individuals against conventional medicine some cancer patients omit a highly effective conventional treatment with a completely unproven natural treatment because they are brainwashed to think everything from mainstream medicine is not effective. Some patients are literally choosing to omit 90% chance of 5 year survival with new drugs like gleevec for a possible 0% chance 5 year survival. This is the cancer patients right to do so of course but i just hope the decision is being made for the right reasons and not just because of the hate they have for conventional medicine.

      I will be the first to say I am disappointed by how our healthcare system is ran and how cancer patients are being treated. However, that is for a different conversation and a whole different battle altogether. My goal right now is to get people to look at cancer treatments as not conventional vs natural but positive data (potential) vs no data or negative data (unknown or no potential). To sum it up, just pick the treatment with the best possible odds of success that still fits the guidelines of your individual criteria regardless of origin. Don’t let your own bias get in the way of a more effective treatment if available.

      • Joel rosenblum 3 days ago

        Keep in mind one reason that people are skeptical of pharma treatments is because the drug studies are paid for by the people trying to profit from positive results. The FDA doesn’t require or even have any way to require all studies to be considered, so even if a company is honestly reporting results, they can be reporting an outlier study and not reporting the others.
        If you actually read the various studies on each drug you will find they often have strikingly different results for the same age/sex/race cohorts. For example, one study will say that X drug didn’t help white north american women over age 50 anf the other will say that is the group that benefitted most. Both studies will be relied upon by the FDA to declare the drug to be overall safe and effective.

        There are a lot of safe and effective natural cancer remedies. They work on different pathways and are often synergistic. One of the most promising is this artemisinin protocol.

  4. Karen 4 years ago


    Can you give a brand and dose for MELATONIN for cancer? I’m trying to help my sister she will be starting chemo. Is this safe to take with chemo treatment?

    • Author
      Cancermind 4 years ago


      Dosage used in studies range from 20 mg to 40 mg per day. Brand is less important as long as it’s from a trusted and credible company. I will be updating the article to showcase which brand I personally use for reference. You can also use this link as well.

      Studies show that melatonin is pretty safe across the board. In fact, a non-small cell lung cancer randomized trial showed melatonin in combination with chemotherapy increased the 5 year survival rate vs chemotherapy alone. Study also showed that patients who took melatonin were able to tolerate chemotherapy better.

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